Role of Therapies in Addressing Health Impacts of Climate Change

Last year, we stepped up to address climate change. As we began putting our thoughts on a new initiative this year, one question lingered: Is there more we can do? The answer was a unanimous and resounding “YES.”

Climate change remains a relentless challenge, demanding continuous action. Recognizing this, we have committed to evolving alongside the ever-changing climate by developing innovative solutions to meet its growing healthcare impacts.

Among the various solutions, advanced therapies have transformative potential in addressing diseases caused by climate change. 

Traditionally employed for chronic and genetic disorders, treatments such as CAR-T, cell therapies, gene therapies, and monoclonal antibodies (mAbs) are increasingly adapted to tackle climate-related health challenges due to their precision, adaptability, and long-term impact.

Advanced Therapies We Provide

1. Cell Therapies

Pollution is taking a toll on human health, particularly respiratory systems. Cell-based therapies utilize living cells to repair, restore or enhance the function of damaged tissues or organs. 

Mesenchymal stem cells (MSC), for example, show promise in repairing lung tissue damaged by pollutants and reducing inflammation in conditions like Chronic Obstructive Pulmonary Disease (COPD) or asthma. MSCs also address tissue damage caused by prolonged heat exposure, which affects cardiovascular and respiratory health. 

Cellular treatments also improve immune responses in vector-borne diseases like malaria and dengue, which are increasingly prevalent due to disease-carrying vectors driven by climate change. These regenerative cell therapies mitigate damage from dehydration and heat-related organ dysfunctions. 

Read More Blog:- Advanced Cell and Gene Therapy in Cleanroom Systems: Ensuring Precision and Safety

2. CAR-T Therapy (Chimeric Antigen Receptor T-Cell Therapy)

Climate change is increasing the spread of diseases caused by evolving pathogens such as HPV and hepatitis. These infections are often linked with certain cancers. CAR-T therapy reprograms the body’s immune cells to effectively target such diseases worsened by environmental factors. 

By engineering T-cells to recognize and destroy infected or malignant cells, CAR-T offers personalized solutions for cancers linked to climate-aggravated infections. 

The therapy strengthens immune responses in individuals with compromised immunity due to environmental stressors.

3. Gene Therapies

Gene therapy involves modifying genes to treat or prevent diseases. Gene-editing tools like CRISPR can modify genes in pathogens or human cells to counteract emerging infections due to climate-induced ecological changes. 

Gene therapy addresses inherited conditions like sickle cell disease, which worsens under extreme heat. This therapy is being explored to modify the genetic traits of vectors like mosquitoes to eliminate the transmission of malaria and dengue and help reduce human health impacts. 

These advancements hold promise for creating resistance to new pathogens arising from changing ecosystems.

4. Monoclonal Antibodies (mAbs)

Monoclonal antibodies are lab-engineered proteins designed to target specific molecules in the body. mAbs are being developed to combat infectious diseases like dengue, Zika, and other vector-borne illnesses spreading due to climate change. 

mAbs also regulate immune hyperactivation in sepsis, a condition often resulting from climate-driven infectious diseases. 

Checkpoint inhibitors, a class of mAbs, have shown efficacy in treating cancers caused by environmental factors like UV exposure and pollution.

Read more blog:- Embarking on the Journey of Monoclonal Antibody (mAbs) Production

Emerging Innovations and Fabtech’s Contribution

• Combination Therapies:

Integrating CAR-T, gene, and cell therapies with traditional treatments can tackle complex diseases influenced by climate change. Fabtech leverages its engineering solutions to create optimized facilities for such therapeutic processing.

Fabtech combines its unique expertise and meticulous manufacturing to bring solutions that elevate the safety and quality standards of the projects. Our state-of-the-art cleanroom systems with positive pressure environments protect sensitive processes from airborne contaminants. 

Our HVAC systems, equipped with HEPA filters at supply terminals, ensure ultra-clean air quality critical for therapy production. These clean air solutions are designed to prevent the entry of external pollutants and maintain stringent standards required for cutting-edge therapeutic development.

• Personalized Medicine

Our Design | Build | Engineer solutions facilitate the development of targeted treatments for climate-induced illnesses. Our infrastructure supports genomic and cellular insights required to study the impact of environmental stressors on cellular function and design therapies tailored to individual needs.

• Vaccination Support: 

Fabtech’s contributions to vaccination support are equally impactful. 

Our equipment, including specialized radioisotope handling solutions, plays a pivotal role in enhancing vaccine efficacy against climate-driven pathogens. 

By ensuring the precision and sterility of injectable therapies, we help bolster global efforts to mitigate the spread of climate change diseases. These solutions not only support the production of conventional vaccines but also enable the development of advanced immunization techniques tailored to evolving pathogens.

As climate change continues to affect global health, advanced therapies provide innovative, adaptable solutions to combat emerging diseases, repair tissue damage, and bolster immune defenses. 

Fabtech’s commitment to excellence in engineering solutions in pharma, and biopharma projects ensures the delivery of safe, high-quality processing of complex diseases. 

With this integration, we take a step to mitigate the rising burden of climate-induced health crises and meet the evolving needs of healthcare systems. Let us partner with you in your next endeavor to advance a resilient and sustainable healthcare future.